Autoimmune Encephalitis

The purpose of this paper is to provide a comprehensive review recent literature data for autoimmune encephalitis (AIE). AIE refers inflammatory, non-infectious, immune-mediated characterised by neuroinflammation, synthesis neuronal autoantibodies (NAAs), directed against surface, synaptic and intracellular antigens, with subsequent dysfunction. It heterogeneous anatomic-clinical syndromes prominent neuropsychiatric symptoms. Due overlapping different clinical diagnostic biomarkers, often considered diagnosis exclusion requires an extensive work-up. Systematic search the term «autoimmune encephalitis» in PubMed database was performed, limitation set systematic papers English, published from 2004- 2022. Further analysis performed author’s reference list Autoimmune Encephalitis Alliance (AEA) website. conducted according PRISMA (The Preferred Reporting Items Reviews Meta-Analyses) guidelines. Outcomes that were sought included: classification presentation; processing; treatment. Preset reviews database, derived eighty six papers. screening data, AEA website previously defined out- comes. Finally, sixteen independently selected thoroughly analysed, relevant conclusions present- ed paper. severe inflammatory central nervous system (CNS) disorder complex differential remains unrecognised. research has established wide range new antibodies syndromes, which have improved approach Initial application immunotherapy improves outcome disease.